Amines react with ketones whereas amides do not. Can anyone please explain why?
closed as off-topic by Todd Minehardt, airhuff, Klaus-Dieter Warzecha, ringo, bon Mar 10 '17 at 13:12
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Protonation of the carbonyl group of a ketone allow amines to react via nucleophilic addition. This is because the added proton pulls electrons further away from the reaction site, thereby allowing the lone-pairs from the amine to attack the carbonyl carbon.
In the case of an amide, the C=O beside the nitrogen causes electrons to be pulled away because of the positive charge of the carbon. This means that despite the possibility of having a protonated ketone, there will still not be a reaction because the nitrogen is not nucleophilic.