I have questions about the involvement of the electron transport chain (ETC) in the biochemical conversion of ethanol to acetic acid. In which of the reaction steps is the ETC employed?

  • $\begingroup$ I just made a question from your water comment.. as it merits a separate question chemistry.stackexchange.com/questions/69388/… Hopefully somebody here will know/post an answer. You can comment on it if you want, though i'm not sure if 16 points will be enough rep to, but if not and you want to comment then you could do so here as it doesn't require much rep to comment on your question or an answer to your question. $\endgroup$
    – barlop
    Feb 27 '17 at 12:44

The principal conversion of ethanol to acetaldehyde takes place in the cytosol of liver cells, no ETC involved directly. This is mediated by the enzyme alcohol dehydrogenase (ADH). However, the NADH produced as a consequence would indeed deliver its electrons to the ETS, an electron transport chain.

The acetaldehyde is then metabolized to acetate in the mitochondria. Again, the involvement of the ETS is in accepting electrons from the NADH that is also produced in this step.

Here's the details: https://pubs.niaaa.nih.gov/publications/arh294/245-255.htm

  • $\begingroup$ Also further, acetate can react with Co-enzyme A to form acetyl coenzyme A. Which is used in a reaction with oxaloacetate to form citrate. Coenzyme A will form a thioester bond and can later be used in a reaction in conjunction with NAD+ and alpha-ketoglutarate to form succinyl-CoA and NADH. $\endgroup$
    – Bob
    Feb 26 '17 at 19:32
  • $\begingroup$ @Bob. True. I limited my response to the OP's purview. $\endgroup$
    – bpedit
    Feb 26 '17 at 20:34
  • $\begingroup$ Of course! I just thought I'd add a little extra since I personally would have also been curious about where the carbon goes. $\endgroup$
    – Bob
    Feb 26 '17 at 20:41
  • $\begingroup$ Many thanks guys for the input. I really appreciate it. $\endgroup$
    – Lobell
    Feb 27 '17 at 7:52
  • 1
    $\begingroup$ Also There's a water molecule in the second reaction where acetaldehyde goes to form acetate. Where does this water come from as it is not produced in the first step. $\endgroup$
    – Lobell
    Feb 27 '17 at 7:55

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