What is the proper procedure for working with KHMDS? I would like to use it to deprotonate a compound and have a bottle of KHMDS in toluene. Does it need to be handled under inert atmosphere? And is it soluble in halogenated solvents?
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$\begingroup$ Did you look at the MSDS or any other literature pertaining to KHMDS or would you rather have someone else give you the answer without you doing the work? $\endgroup$– NopeSep 27, 2013 at 18:12
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$\begingroup$ SDS's are nice but they tend to give safety instructions appropriate for tanker rail car volumes of material. (i.e. why do I need a respirator, face shield, apron, and gloves for everclear and table salt salt?) $\endgroup$– A.K.Dec 16, 2015 at 2:00
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If you would look up the properties of KHMDS from a chemical supplier, you will find it will react violently with with water. So do keep it under inert atmosphere.
As for solubility, it is a non-nucleophilic base, so probable no substitution and addition like reactions will occur. I wont suspect it will be a problem there.
A comment on the use though. If you plan to use this, explore the dangers and possibilities of a substance like this a bit further than asking it here. For safety considerations. Look up the MSDS sheets from your supplier and be sure to only use this in a properly equipped lab.
Hope this helped.
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1$\begingroup$ I checked the msds right after posting the question and read up on it and was able to carry the reaction out successfully. Thanks for your response. $\endgroup$– AmadiSep 28, 2013 at 15:14