What is the proper procedure for working with KHMDS? I would like to use it to deprotonate a compound and have a bottle of KHMDS in toluene. Does it need to be handled under inert atmosphere? And is it soluble in halogenated solvents?

  • $\begingroup$ Did you look at the MSDS or any other literature pertaining to KHMDS or would you rather have someone else give you the answer without you doing the work? $\endgroup$
    – Nope
    Sep 27, 2013 at 18:12
  • $\begingroup$ SDS's are nice but they tend to give safety instructions appropriate for tanker rail car volumes of material. (i.e. why do I need a respirator, face shield, apron, and gloves for everclear and table salt salt?) $\endgroup$
    – A.K.
    Dec 16, 2015 at 2:00

1 Answer 1


If you would look up the properties of KHMDS from a chemical supplier, you will find it will react violently with with water. So do keep it under inert atmosphere.

As for solubility, it is a non-nucleophilic base, so probable no substitution and addition like reactions will occur. I wont suspect it will be a problem there.

A comment on the use though. If you plan to use this, explore the dangers and possibilities of a substance like this a bit further than asking it here. For safety considerations. Look up the MSDS sheets from your supplier and be sure to only use this in a properly equipped lab.

Hope this helped.

  • 1
    $\begingroup$ I checked the msds right after posting the question and read up on it and was able to carry the reaction out successfully. Thanks for your response. $\endgroup$
    – Amadi
    Sep 28, 2013 at 15:14

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service and acknowledge that you have read and understand our privacy policy and code of conduct.

Not the answer you're looking for? Browse other questions tagged or ask your own question.