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Can we generalize on the basis of number of chirality centers if an organic molecule is chiral or not?

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There is a general statement. If the molecule has any improper axis of rotation, it is achiral.

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  • $\begingroup$ What is an "improper" axis of rotation by the way. Can you please elaborate on that? $\endgroup$ Commented Oct 7, 2016 at 14:09
  • $\begingroup$ Rotation + reflection through a plane perpendicular to the axis. If you can do that to the molecule and have it look exactly the same. It is not chiral. $\endgroup$
    – Zhe
    Commented Oct 7, 2016 at 17:25

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