Sadly my chemistry background is only from high school (I'm a roboticist), but I try my best to explain the problem:
Situation: Lets say I have two water based solutions/suspensions. One contains cells with A-hooks and one contains proteins with B-hooks. Now i mix those two liquids and then the As will attach to the Bs. And so they will form sort of a polymer (not sure if this is the right phrase here)
Question: Now is there a model that tells me how "well" the polymerization works, dependent on the concentration of the two solutions, temperature, affinity of A to B, whatever other parameters there might be. I think a good measure for "good polymerization" would be the distribution of lengths of the chains or connectivity or some other graph metric.
The Background is the idea to build a 3D tissue printer without support structures. A and B refers to Biotin and Streptavidin
- each cell will have several 100 A-hooks, the proteins can be engineered to have an arbitrary number of B-hooks (we would like to optimize that)
- to make it work we obviously need to connect each cell with as many different individual proteins as possible and vice versa.