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This is a continuation to a previous question of mine regarding a change to a one-pot procedure for the preparation of Wellbutrin that I performed in college last semester. Could toluene have been used as the extraction solvent for the a-bromoketone and for the nucleophilic substitution? The procedure we were given used DCM and then removed it under vacuum for a solvent switch to NMP. Also, what was the reason for this? Could a mixture of NMP and DCM have been used?

Previous question: Suggestions for solvents capable of efficiently performing alpha-bromination and nucleophilic substitutions

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  • $\begingroup$ Please provide a link to your previous question. $\endgroup$ – f'' Jul 26 '16 at 2:07
  • $\begingroup$ I added the link in an edit. $\endgroup$ – Jeffrey Schultz Jul 26 '16 at 11:55

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