# How to Protect one -OH group in 1,4-benzenedimethanol using TBDMS

Actually i want to protect one -OH group using using 1.1Eq of TBDMSCl and 1.5 Eq of Imidazole. Is is possible to protect one OH group using these condition. Even if i get mixture of Products ( one protected OH and Both OH protected compounds), separation by column would be easy and what would be approximate yield of both products.

any suggestions.?

• Welcome to Chemistry.SE! Take the tour to get familiar with this site. Mathematical expressions and equations can be formatted using $\LaTeX$ syntax. This appears to be a homework question, please share your thoughts and attempts towards the solution. If you have a procedure you are working on, please provide a citation to it. Possibly the context of it might already explain the selectivity of such a reaction. – Martin - マーチン Jul 20 '16 at 8:07