I was wondering if there is a decent and non-complex way to predict the outcome of mixing two chemicals together.
I know that molecular dynamics is used in computational chemistry to understand some of these types of problems, but in many cases I have noticed that they seem to be restricted to classical physics and therefore cannot accurately predict any real reactions.
My point in asking is such that I can have a broader understanding of this; However, at the moment, I am interested in the difference between this reaction:
and the same reaction while replacing the triflic acid ($\ce{CF3SO3H}$) with chlorosulfonic acid.
Would there be any differences if these two superacids were switched?
The paper from which I obtained this reaction from is here:
Klumpp, Douglas A., Rendy Rendy, Yun Zhang, Alma Gomez, and Aaron McElrea. "Dicationic Intermediates Involving Protonated Amides: Dual Modes of Reactivity Including the Acylation of Arenes." Organic Letters 6, no. 11 (2004): 1789-1792.