# Does mechanotransduction of cells play a role in the biocompatibility of titanium?

What exactly is mechanotransduction? The definition seems to vary from source to source. Some indicate that mechanotransduction is the underlying principle where cells pull on the surface they grow on to test their stiffness, so they can stretch and facilitate cell growth and differentiation. Others indicate that mechanotransduction is how cells detect mechanical stimuli and turn them into chemical signals like our four senses (touch, hearing, smell, etc).

Also, is this the main reason titanium is biocompatible to replace bones because it has a low surface resistance and cells can stretch on it?

Cellular response to a foreign object is the result of largely chemoreception. Interaction at the implant-cell surfaces determines how an implant will be perceived by the body. Titanium's biocompatability is a result of the protective oxide film that forms on the surface of the metal in the presence of oxygen. This oxide film is strongly adhered, insoluble in water, and chemically impermeable, preventing reactions between the metal and the surrounding environment. Titanium's high dielectric constant allows it to be easily integrated into cells and bone tissue$^{[1]}$.