I'm trying to understand the drug development stages, techniques and procedures. My understanding on the subject:

Microscale experimentation

  • Is used on early stages to find compounds reacting with some target proteins/whatever
  • Is done on a very small scale (< 1mg) since most of the compounds are not going to react with the target
  • Techniques: Combinatorial Chemistry

Preparative Synthesis

  • Is done on later stages when we found a number of potentially useful compounds
  • Is used to synthesise compounds in larger quantities (5-200mg) for further testing and possible conversions to other compounds with better characteristics (e.g. lower toxicity or better distribution). We need larger quantities because we will conduct a lot of experiments with these compounds down the road (including microscale experimentation?)
  • Techniques: High-Throughput Chemistry

Could someone please correct and possibly extend my explanation?

  • 1
    $\begingroup$ What exactly do you want clarification about? You seem pretty clear on the subject to me. $\endgroup$ – bon Mar 28 '16 at 10:21
  • $\begingroup$ I didn't know if I was understanding all the details correctly, wanted to confirm my vision. If you're saying that everything is okay, then I'm happy :) $\endgroup$ – Stanislav Bashkyrtsev Mar 28 '16 at 11:08

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