I have 50 ml of a compound I would like to purify. Since the impurities presents have close boiling points (b.p.), I have to use fractional distillation. Am I going to lose significant quantity of my product volume because of loss related to the distillation itself?
If so, what can I do to minimize the loss?
I thought about adding a higher b.p. solvent to the distillation flask so I can distill all the compound without leaving some in the flask. What do think about this method?
Are there any other strategies?