I know that flooding will ruin the performance of a distillation column. There are many correlations (Eckert, kister, billet, etc.) that will tell you when a column will flood based on your fluid conditions. Most design guides suggest choosing a diameter that will lead 70-80% of the flooding condition. This makes sense as the size of the column (IE, the cost) is as small as possible while still giving you a 20-30% margin of error.
However, what if due to other constraints you want the column to be large so that it is only operating at 10% of the flooding conditions (IE, a much larger diameter than normal). Would this column still operate? Is this type of operation just avoided because it is not economically practical and a smaller column would do the same thing operating closer to flooding?