The chemical structure of the compounds in question are:


Figure 1: Hyperforin

enter image description here

Figure 2: Tetrahydrohyperforin

enter image description here

Figure 3: Octahydrohyperforin

Would heating hyperforin in the presence of water manage to saturate the required bonds and thus allow one to synthesise these compounds?


1 Answer 1


That route won't work.

You need a hard base reduction that does not attack the enone, or you need to protect the enone to make Tetrahydrohyperforin.

Catalytic hydrogenation that is selective against carbonyl reduction is necessary to make Octahydrohyperforin.


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service and acknowledge you have read our privacy policy.

Not the answer you're looking for? Browse other questions tagged or ask your own question.