We are aware that one of the basic information about a material is the logP value it has. The logP is worked out from the partitioning between the octanol and the water phases. Does anyone know who was the first to introduce this octanol-water partition coefficient? I had a look through the literature but was not able to find the author of that rule.

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    $\begingroup$ Solid-state-chemistry? Really?? $\endgroup$ – bon Sep 21 '15 at 14:32
  • $\begingroup$ well, no relevant tags available (the ones I thought of at least). I tried to add some myself, but my reputation is still very low to do so. Thanks for the new tags :) $\endgroup$ – Error404 Sep 21 '15 at 15:00
  • $\begingroup$ I didn't create any new tags, I only added existing ones which you could have done yourself. $\endgroup$ – bon Sep 21 '15 at 16:25

The most oft-cited publication is Partition Coefficients and Their Uses. A. Leo, C. Hansch, and D. Elkins. Chemical Reviews 71(6), 525-616 (1971). This manuscript was noted as a "Citation Classic" (see text here) in which A. Leo writes (in part):

In recognition of the effort of designing a method of calculating log P (o:w) from structure, the early version of which was reported in this article, the Chesapeake section of Sigma Xi presented me with its Excellence in Science Award for 1980.”

Note bene: In the last article I've linked, mention is made that the phenomena was first investigated by Bertholet in 1872 and "put on a firm basis by Nernst in 1891." That said, the 1971 publication of Leo $\it{et\; al}$ is the first modern/comprehensive listing of octanol-water partition coefficients and the place where the symbology (and definition) were written.


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