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I just learned that charged alpha helices are less thermally stable than uncharged ones. The only difference I see between them would be a larger dipole moment in the charged helix, but how would this contribute to stability?

Here a picture for clarification:

Two alpha helices

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  • $\begingroup$ I am not sure about the thermal stability but carboxy-terminal amidation can protect from carboxypeptidase digestion. That is just biochemical stability. Can you indicate where exactly you read about what you are asking (add links if you can or paste an excerpt) $\endgroup$ – WYSIWYG Sep 12 '15 at 13:31
  • $\begingroup$ It was an exercise sheet: goo.gl/x1xiaj - Unfortunately, there are no online solutions, but in class, they told us that charged alpha helices are less thermally stable than uncharged ones (see question). $\endgroup$ – ste Sep 13 '15 at 13:30

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