# Attachment of disulfide (protected) thiolated oligonucleotide on gold surface

What will happen if I incubate a clean gold surface in un-deprotected ($\ce{oligo-C6-S-SH}$) thiolated oligonucleotide solution instead of deprotected ($\ce{oligo-C6-SH}$) solution. I have read clean gold surface can cleave disulfide bond.

• I don't have references at the ready, but I would expect the disulfide would cleave and you'd end up with oligo-$\ce{C6}$-S-Au on your surface – Geoff Hutchison Jul 13 '15 at 22:43
• How stable are those hydrodisulfides? Wouldn't they be prone to disproportionation to things like oligo-S-S-oligo, oligo-S-S-S-oligo, and oligo-SH? – Curt F. Jul 13 '15 at 23:44