# pH effect in the hydrophobic interactions between two polypeptide chains

The rise in pH can change the protein conformation by changing the ionic interactions and hydrogen bonds between two polypeptide chains. This is a fact that I understand very well because the change in amino-acid ionization with pH. I would like to know if by changing the pH value the hydrophobic interactions between two chains can also be changed. If yes, what is the mechanism? Article: a pH Induced increase in hydrophobicity...