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With respect to related R class in KEGG website:
http://www.genome.jp/tools-bin/relclass?RC00064

What is the biological or statistical relevance of the score? How is it computed? And does it signify the bonding strength of how probably it is for a pair of compounds to be an R pair?
Note: This may be a silly question to all chemists, but not for me, i am a computer science student , and my research field in bioinformatics and so i have to study both biology and bit of chemistry, so please just dont close the question or be harsh on me, I have very little knowledge in chemistry and also googling doesn't help much. I asked this question in Biology forum, they closed the question and asked me to ask it here

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    $\begingroup$ This question could also profit from more context and an actual title. $\endgroup$ – Martin - マーチン May 19 '15 at 4:31
  • $\begingroup$ genome.jp >> KEGG >> KEGG Overview >> R number $\endgroup$ – John Snow May 19 '15 at 5:42
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And does [the score] signify the bonding strength of how probably it is for a pair of compounds to be an R pair?

No, it has nothing to do with that. It is not about how probably a particular reaction is.

When comparing RCs (reaction classes), the scores in the table of related reaction classes are just a measure on how similar these reactions are.

RC00064 apparently is an N-acylation or the formation of a peptide bond. RC00197 with a score of 1.0 is a N-formylation and considered very similar.

Change the cutoff to a lower value, such as 0.4, and compare the results at the end of the table with RC00064. You'll find dissimilar reaction classes like RC02518, the oxidation of a selenol to a selenic acid.

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