Are there any limits to rotating a compound in order to prove that its chirality or achirality? (assuming that you're rotating about a single bond)
I think what you may be asking is: could there could be a nominally "meso" compound that has restricted rotation about its central single bond, causing it to exist in the form of two non-interconvertible stereoisomers. Example- start with meso-tartaric acid, and make the di-tert butyl ether from the OH groups and di-tert-butyl ester from the COOH groups. Maybe these groups would be bulky enough to restrict rotation. You could mentally rotate around the central C-C bond until the molecule has a plane of symmetry, so it is still a nominally "meso" compound, but physically you could separate the two stereoisomers.
Rotating about a single bond would be a conformational change and not a stereochemical one. Meso compounds are not defined as having rotational symmetry, either way. For example, 1,2-diphenylethane-1,2-diol does not have rotational symmetry since one carbon is R and the other S. However, it's still a meso compound because its mirror image can be rotated to show that it is identical to the original compound.