# Can decarboxylation be done under carbon dioxide?

From Why is the decarboxylation of 2-hydroxybenzoic acid (and related compounds) done 'under nitrogen'? I confirmed that nitrogen is used to exclude oxygen - in order to prevent oxidation of the material.

Can $\ce{CO_2}$ be substituted for nitrogen, or will the presence of carbon dioxide slow down the decarboxylation reaction (which is causing carbon dioxide to be released)?

• Carbon dioxide is relatively reactive in comparison to nitrogen and argon. You cannot assume your $\ce{CO2}$ blanket won't interfere with your reaction. – Jori Mar 22 '15 at 11:50
• @Jori "You cannot assume your CO2 blanket won't interfere with your reaction." ..hmm. Not good. But are you saying that you know it will interfere with decarboxylation reaction, or more that it is (simply) rash to presume it will be OK? BTW - how did you make that 2 as a subscript in a comment? I use <sub>..</sub> for the question. – Andrew Thompson Mar 22 '15 at 11:57