# Substitute solvent for diethyl ether?

I want to run a reaction that needs diethyl ether as anti solvent in the last step (comes from articles). But I can't use it due to its harmful effects on the body. Is there any other solvent?

My reaction is about substitution of $\ce{-OH}$ of lignin with BiBB in THF and in other one in $\ce{EtOAc}$ as solvent.

• Welcome to Chemistry.SE! To acquaint yourself with this page, take the tour and visit the help center. Furthermore this tutorial shows you how math and chemical formulae can be nicely formatted on this site. Please include references to the articles you are referring to in your question and when you use "non-trivial" abbreviations such as BiBB it would also be nice to include a link to some site that shows what hides behind the abbreviation. – Philipp Dec 6 '14 at 11:53
• I've added a link for BiBB. If its not the correct compound please change it. – Philipp Dec 6 '14 at 11:55

• However, if you are worried about one of the other ways diethyl ether is more hazardous than THF, then we have a different scenario. Diethyl ether has a lower boiling point (ca. $35\ ^\circ \text{C}$), which means it is much more likely that you will be exposed to the 50 mg/day vapor. Also, in some parts of the world, especially if there is no air conditioning, diethyl ether might be a gas. Diethyl ether also is more flammable (due to its higher volatility), and forms peroxides more quickly (and more explosively). – Ben Norris Jan 7 '15 at 12:21