I am studying the synthesis of a drug pregabalin, for which both chemical and bio-catalysts are used. Using a biocatalyst is way better than chemical route, as explained here. In fact, The invention of the bio-catalyst route got 2006 IchemE award in Green Chemistry and Engineering.
I am interested in knowing is this: are there any disadvantages of using bio-catalysis in this reaction? (Some general disadvantages can be seen here) Suppose you are in a debate and you have to favor the chemical side, what would be your arguments?