Can the 1st generation Grubbs Catalyst be used for ring closing metathesis on non-terminal alkenes?

Question

I'm wondering if the 1^st generation Grubbs catalyst can be used to do ring closing metathesis on a non-terminal alkene.

Answer 1

Yes, it appears that that ring closing metathesis of non-terminal alkenes has been performed using the 1st generation Grubbs catalyst several times:

• Asymmetric syntheses of enantiopure C(5)-substituted transpentacins via diastereoselective Ireland–Claisen rearrangements
• Stereoselective Synthesis of Deuterium-Labeled (2S)-Cyclohexenyl Alanines, Biosynthetic Intermediates of Cinnabaramide
• Ru-catalyzed metathesis of octadienylether xyloside Synthesis of (−)-Agelastatin A by [3.3] Sigmatropic Rearrangement of Allyl Cyanate
• A chiral auxiliary cleavable by ring-closing alkene metathesis — Efficient synthesis of chiral nonracemic cycloalkenes
• Conversion of chiral unsaturated cyanohydrins into chiral carba- and heterocycles via ring-closing metathesis
• Total Synthesis of Pancratistatin Relying on the [3,3]-Sigmatropic Rearrangement
• Stereoselective Chelate-Controlled Addition of Grignard Reagents to Unsaturated Medium-Ring Heterocycles