Is the following the correct designation (S) for the chiral carbon in a skeletal representation of 1-chloro(3-13C)butan-2-amine?
The CIP rules say to go one at a time by each rule until you find an answer:
1a. Higher atomic number.
1b. Go down the chain until a difference is found.
2. Higher atomic mass.
In this case, even though the $\ce{^{13}C}$ is a higher atomic mass than the $\ce{^{12}C}$, the isotope is ignored because rule 1b says to go down the chain to find a difference based on atomic number first, before atomic mass. Am I correct?
I don't have access to the IUPAC book that has all the rules and many examples, so I used Hanson et al. [1] as my source to get my answer.
Reference
- Hanson, R. M.; Musacchio, S.; Mayfield, J. W.; Vainio, M. J.; Yerin, A.; Redkin, D. Algorithmic Analysis of Cahn–Ingold–Prelog Rules of Stereochemistry: Proposals for Revised Rules and a Guide for Machine Implementation. J. Chem. Inf. Model. 2018, 58 (9), 1755–1765. DOI: 10.1021/acs.jcim.8b00324 (PDF)