I need help formulating an elementary stepwise mechanism from Leflunomide to Teriflunomide. Even just how to start this process, I keep getting stuck after trying to open the isoxazole ring.

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    $\begingroup$ This proceeds by deprotonation of the isoxazole. Remove the proton next to the isoxazole nitrogen and break the N-O bond $\endgroup$
    – Waylander
    Feb 1 at 7:03


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