We all know that polar amino acids like Serine, Threonine, Glutamine etc. form H-bonds using their side chains. Is it possible for aliphatic Amino acids to make H-bonds using their side-chains?

  • $\begingroup$ Alkyl hydrogens do not hydrogen bond $\endgroup$
    – Waylander
    Mar 19 at 13:19
  • $\begingroup$ @Waylander why not? $\endgroup$
    – Volpina
    Mar 19 at 19:38
  • $\begingroup$ Carbon is not electronegative enough so there is little difference between carbon and hydrogen electronegativity. Hydrogen bonding only arises when hydrogen is attached to a highly electronegative element (see ncbi.nlm.nih.gov/pmc/articles/PMC3516709) $\endgroup$
    – Waylander
    Mar 19 at 21:22


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