4
$\begingroup$

This says that aminoguanidine interferes with the formation of advanced glycation endproducts (AGEs) through interacting with 3-deoxyglucosone.

But how does it interact with 3-deoxyglucosone that prevents AGE formation?

$\endgroup$
  • $\begingroup$ What is AGE? Please define your acronyms for the benefit of those who are not familiar with the jargon. $\endgroup$ – iad22agp Oct 8 '14 at 13:09
  • $\begingroup$ okay i've added it $\endgroup$ – InquilineKea Oct 8 '14 at 20:41
2
$\begingroup$

I would expect the N-amino group of aminoguanidine to react with 3-deoxyglucosone at either of the adjacent, reactive carbonyl groups to form a stable guanidinylimine derivative (analogous to a hydrazone). This derivative, unlike 3-deoxyglucosone itself, would not be able to react with free amino groups on proteins and continue on the pathway to AGEs, but rather would be excreted as is.

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.