This says that aminoguanidine interferes with the formation of advanced glycation endproducts (AGEs) through interacting with 3-deoxyglucosone.

But how does it interact with 3-deoxyglucosone that prevents AGE formation?

  • $\begingroup$ What is AGE? Please define your acronyms for the benefit of those who are not familiar with the jargon. $\endgroup$ – iad22agp Oct 8 '14 at 13:09
  • $\begingroup$ okay i've added it $\endgroup$ – InquilineKea Oct 8 '14 at 20:41

I would expect the N-amino group of aminoguanidine to react with 3-deoxyglucosone at either of the adjacent, reactive carbonyl groups to form a stable guanidinylimine derivative (analogous to a hydrazone). This derivative, unlike 3-deoxyglucosone itself, would not be able to react with free amino groups on proteins and continue on the pathway to AGEs, but rather would be excreted as is.


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