In a collision between two molecules, can the relative velocity of one with respect to the other be too large for a reaction to occur? For example, suppose that two molecules collide with (a) a perfect orientation to enable a reaction and (b) kinetic energy in excess of the activation energy, but their relative velocity is very large in magnitude. Will the two molecules simply bounce and part ways chemically unchanged?
One important thing to remember is that rarely is there ever only one possible reaction for two molecules to engage in; we often make distinctions between "kinetic" reactions (reactions that occur because their activation energies are low) and "thermodynamic" reactions (reactions that occur because the products have favorable energies). However, every reaction we'd reasonably do in a lab is technically a "kinetic" reaction, because extremely high-energy velocities will eventually surpass the activation barriers to extremely unstable products like carbanions and random molecular fragments. Basically, go fast enough and your molecules will just explode on contact. We like to think of gas-phase molecules as billiard balls bouncing around, and that can be a pretty good model! Especially considering that if you hit two billiard balls together fast enough, they will also just explode.
So we're asking "are there kinetic energies below the activation energies of competing reactions that will make collisions faster than the time-scale of bond formation?" And the answer is a very confident "no"—bond formation and rearrangement occurs on the femto- and picosecond time-scales (mere billionths of a second long) and there is simply no way to make them go fast enough such that they'd spend too little time in the regions where suitable electron-wavefunction overlap for a transition-state occurs, especially if you were hoping they don't just explode.
If you're interested in high-energy reactions, I recommend exploring some of the theoretical mechanisms behind fragmentations in mass spectrometry. Much of mass spectrometry leverages kinetic energy to access high-energy fragmentary reactions for structural analysis of compounds.