1
$\begingroup$

The pKa of sulfuric acid, which is usually used to do this reaction is -3, but would TFA be sufficient even though it has a pKa of 0.5?

$\endgroup$
0
1
$\begingroup$

Yes. TFA is widely used for alcohol dehydration, for example as described in this review.

TFA is a standard reagent for the ionic hydrogenation of alcohols with hydrosilanes which proceeds via the protonation of the alcohol and the formation of the cation wikipedia article

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.