# How would I go about developing a linker molecule that binds SiO2?

I'm trying to develop a molecule that acts as a bridge between a protein and surface of SiO2 lattice. The end that binds the protein is simple and easy but I can't figure out a way to draft up how I can get the other end to bind SiO2.

So my question is, anyone have an idea on what particular molecule or reaction I can look at that targets Silicon molecules or has a high affinity for binding specifically SiO2? It doesn't even have to be a chemical bond that links the bridge to the SiO2, it could be an electrostatic/polar interaction too.

Thank you.

• You should search silane chemistry. Molecules can be easily bound to silica using functionalized triethoxysilane. Jun 27 at 20:45

It is not easy to bind an organic molecule to silicium oxide. It is necessary to synthesize the Si-O bond. It cannot be done starting from $$\ce{SiO2}$$. A possibility is to react $$\ce{CH3Cl}$$ over elementary silicium at high temperature to carry out the reaction : $$\ce{2 CH3Cl + Si > Si(CH3)2Cl2}$$. Another approach is to make methyl sodium $$\ce{NaCH3}$$ react with gaseous $$\ce{SiCl4}$$ to produce : $$\ce{SiCl4 + 3 NaCH3 -> Si(CH3)3Cl}$$. These compounds can react with an alcool, like for example : $$\ce{Si(CH3)3Cl + ROH -> Si(CH3)3OR + HCl}$$. And here you obtain a molecule belonging to the class of the silicone. It contains the bond Si-O-C that you were looking for.