Can I make a phosphate buffer of pH 7.4 starting with phosphoric acid and then adding NaOH until the pH reaches 7.4. What are the disadvantages of using this method over sodium phosphates?

  • 2
    $\begingroup$ this way, you have limited control for the final concentration and you need to involve pH measurement. OTOH, using hydrogen- and dihydrogenphosphate, masses for salts are already tabelized for given pH. $\endgroup$
    – Poutnik
    May 11 at 13:56

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