It is well known that peptides are synthesized by a so called "condensation" reaction between an amine and a carboxylic acid group to form the final amide moiety (because it releases water). In its general form, it resembles the picture below.
However, what is the actual chemical mechanism behind this reaction? My thoughts are that the amine can deprotonate the carboxylic acid and form a carboxylate - which is a very bad electrophile - so how would it form the amide from nucleophilic attack? I am aware that in the body, it is possible that this reaction is mediated by biochemical catalysts but I am still not sure of the overall mechanism. If this reaction does indeed involve biochemical catalysts, is it possible to complete the synthesis without them?