There are plenty of sources saying that the Suzuki coupling is air-sensitive (even though there are some versions that require oxygen). However I'd like to know why a typical Suzuki coupling is air-sensitive. I cannot find what the oxygen actually does. Pd(0) doesn't seem like it would get oxidised in air that easily, does it?

  • $\begingroup$ A Suzuki coupling isn't oxidative; it shouldn't require oxygen. What schemes are these? Can you attach them? $\endgroup$ Commented Mar 5, 2021 at 2:25
  • $\begingroup$ Sure, here pubs.rsc.org/en/content/articlelanding/2011/ob/… $\endgroup$ Commented Mar 5, 2021 at 2:44
  • $\begingroup$ However I'm asking about the normal version where it's done under N2 or Ar, I'd like to know why. $\endgroup$ Commented Mar 5, 2021 at 2:45
  • $\begingroup$ Ah, I now see that perhaps my question was ambiguous. I will try to amend it. $\endgroup$ Commented Mar 5, 2021 at 2:47
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    $\begingroup$ Hmm, I'm pretty sure that the standard one is oxygen-sensitive because Pd(0) is easily oxidised. That oxygen Suzuki is a bit underexplained, there is only a speculative suggestion in an earlier paper by the authors... $\endgroup$ Commented Mar 5, 2021 at 2:57


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