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I need to do an alcohol bromination using PBr3 and I've never done this reaction before. Reading about PBr3 I found it is water/air-sensitive and the bottle I bought doesn't have a seal. So how am I supposed to manipulate it if I can't expose it to air? Just open the bottle and insert an Ar flow rapidly? Is there a more refined procedure to deal with this without a glove-box? I tried reading procedures on papers but they usually just say "PBr3 was added to the flask", nothing else.

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  • $\begingroup$ Hmm, I don't think it's very sensitive. More like too much contact with air decreases yield a few percent sensible, probably. $\endgroup$
    – Mithoron
    Jan 28 '21 at 19:33
  • $\begingroup$ PBr3 is a high boiling liquid that can be measured gravimetrically or volumetrically in a vented hood. $\endgroup$
    – user55119
    Jan 28 '21 at 20:35
  • $\begingroup$ Do you have a nitrogen gas supply? $\endgroup$
    – Waylander
    Jan 28 '21 at 22:25

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