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I have to run a reaction using N,N'-Dicyclohexylcarbodiimide and at room temperature, it is solid, but it's very hard to weigh. I know its melting point is around 40 degrees. Is it better to melt it and measure it as a liquid or is it no worth the struggle? I just don't want to have it in my hands anymore after reading it is very toxic in contact with skin and I feel like I had a few grams in contact with my hands everytime I try to break the chunks and weight it. Any tips on dealing with this reagent?

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    $\begingroup$ Well, you obviously shouldn't touch it with bare hands. I don't think melting is good idea though, for eg. would lead to a bit more reaction with water vapor, I guess $\endgroup$ – Mithoron Jan 28 at 19:30
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    $\begingroup$ Good god, don't touch that stuff. Use gloves and a heavy duty metal spatula. The stoichiometry doesn't need to be perfect, so who cares if you are 5% off. $\endgroup$ – Zhe Jan 28 at 19:56
  • $\begingroup$ Why is it coming into contact with your hands? Do you not routinely use gloves....? $\endgroup$ – orthocresol Jan 28 at 20:01
  • $\begingroup$ I usually break it up wih a heavy duty spatula then weigh it out - using gloves! $\endgroup$ – Waylander Jan 28 at 22:27
  • $\begingroup$ I do use gloves lol. But it's so messy breaking that extremely well packed solid that a lot of it goes in the gloves and of course some of it will reach my skin eventually (and I think in my first reaction I did all the grinding without gloves on and I'm still alive, so maybe I'm a survivor idk) $\endgroup$ – Raul Luciano Jan 29 at 2:00

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