Fomepizole is essential drug for methanol poisoning, I observed it cost too much like in 1000's of dollar for couple of ml. Is cost due to patents, or due to synthesis cost,structure of molecule looks very small and easy, then why so much difficulty in synthesizing molecule ?
Interesting that the cost in the US for the USDA-approved form is US$900 per 1.5 ml IV ampule. (Specific gravity is given as ~1, i.e. 1.5 g per ampule).
That chemical, 4-methylpyrazole, "For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.", is available for US$74 per g .
So if standard use is 1.5 ml, then the research-grade chemical would cost ~US$130 per dose. Is the difference in cost due to difficulty in removing toxic substances from the research grade drug? Is the cost due to licensing fees, set to make a profit and to recover the cost of testing efficacy and safety?
As a side note, ethanol therapy is often used for alcohol dehydrogenase inhibition, to slow metabolism of methanol to formaldehyde, because, "fomepizole is more expensive than ethanol, and its use in pediatrics is off-label." Твоё здоровье!