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According to sources provided below, the oxime HI-6, or Asoxime Dichloride, as it is also called, besides being a reactivator of acetylcholinesterase that has been inhibited by organophosphorus compounds, can act as an AChE inhibitor itself.In the process of inhibiting AChE, does HI-6 form a covalent adduct with the enzyme (Similarly to how TMTFA forms an adduct) or is the inhibition due to HI-6 simply occupying the active site without covalently binding with the enzyme?

References:

  1. Soukup O, Pohanka M, Tobin G, et al. The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder. Neuro Endocrinol Lett. 2008;29(5):759-762.
  2. Pohanka, M. (2012). Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology. International Journal of Molecular Sciences, 13(2), 2219–2238. doi:10.3390/ijms13022219
  3. Pohanka, M. (2013). HI-6 modulates immunization efficacy in a BALB/c mouse model. Environmental Toxicology and Pharmacology, 36(3), 801–806. doi:10.1016/j.etap.2013.07.012
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