In the synthesis, both intra- and intermolecular SN2 can undergo, in which only intramolecular reaction gives the cyclic ethers. However, both reactions happen in the reaction mixture. How can I alter the reaction conditions / add other reagents such that the intramolecular reaction becomes more favorable?
One solution I found is diluting the solution since the rate of 2nd order (intermolecular) reaction drops faster than 1st order (intramolecular) reaction. However, I wonder is it practical to dilute the solution to a large extent for purity, compromising the increased reaction duration and is there any faster and simpler reactions?
question 2: This synthesis involves SN2, so I am thinking if there is a tertiary carbon bonded to the leaving group, it is impossible to form a cyclic ether. Therefore, are there any other ways I can synthesis cyclic ethers with the starting material as monohaloalcohol?