From an article by Frye et al. [1]:

Reduced glutathione (GSH) is the major intracellular redox buffer and is essential in free radical scavenging, redox homeostasis, maintenance of protein redox conformation and regulation of redox sensitive enzyme activity.

What is "maintenance of protein redox conformation"? Is it just fancy phrasing for "keeping proteins properly reduced, but not too much reduced, and properly oxidized, but not too much oxidized?


  1. Frye, R. E.; Rossignol, D.; Scahill, L.; McDougle, C. J.; Huberman, H.; Quadros, E. V. Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder. Seminars in Pediatric Neurology 2020, 100835. DOI: 10.1016/j.spen.2020.100835.
  • $\begingroup$ Ha, ASD seems to be quite a popular topic these days:) The term also appears in a 20 year-old publication doi.org/10.1046/j.1432-1327.2000.01601.x. $\endgroup$ – andselisk Jul 19 '20 at 18:21
  • $\begingroup$ It seems like poor wording. It probably means "maintenance of equilibrium between protein redox conformations". $\endgroup$ – Buck Thorn Jul 20 '20 at 11:07

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