I am having an issue where the MS for my antibody (intact/nonreduced, deglycosylated by PNGase) shows multiple clusters of what appear to be ghost peaks after deconvolution, and the main peak is extremely broad and appears to show a ton of different adducts.
I'm reasonably confident this shouldn't be the case, as the reduced chains are extremely sharp and homogeneous and show the exact expected mass consistently.
Has anyone else observed this phenemenon? Any idea what causes it and/or how to abrogate it?