I'm having a Grignard reaction between a ketone or aldehyde with RMgX in mind. The average workup uses water to hydrolize the intermediate alkoxide. But could this intermediate be used without isolation to prepare an ether or ester? For example by simple addition of RX, tosyl chloride, acetyl chloride ...

I don't know if the compoud is reactive enough, however. But it is an alkoxide and you probably wouldn't even need additional base for e.g. HCl scavenging. Maybe someone here knows more about the reactivity or maybe there are some literature examples?


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.