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I have been reading Peter's Sykes and there I came across certain compounds which show decarboxylation. My doubt is that how the acidity of the groups attached to the carboxyl groups will help in decarboxylation. For example we have one EWG and one EDG then which will show faster decarboxylation.

I am quite aware of the mechanism but somehow I can't relate here.

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  • $\begingroup$ EWG stabilise anions. The key step of decarboxylation is the formation of an anion from the loss of CO2. $\endgroup$
    – Waylander
    Apr 21, 2020 at 10:09
  • $\begingroup$ Yes but here we are proceeding via 6 membered cyclic TS not by anion formation $\endgroup$
    – Alex
    Apr 21, 2020 at 13:12
  • $\begingroup$ A diagram would assist $\endgroup$
    – Waylander
    Apr 21, 2020 at 13:16
  • $\begingroup$ What I mean to say is the decarboxylation mechanism at higher temperature where we assume co2 leaves $\endgroup$
    – Alex
    Apr 22, 2020 at 14:50
  • $\begingroup$ Anyone can help? $\endgroup$
    – Alex
    Apr 26, 2020 at 21:50

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