I'm going to analyse plasma samples that contain a lot of fibrin. It is necessary to centrifuge the samples to be able to pipette the plasma. After the samples are centrifuged I can't vortex them because then I mix everything again and it wont be possible to pipette. Now I wonder whether it is necessary to vortex them before I centrifuge them. I don't think so because during centrifugation particles will anyway be separated by density. Or am I wrong? And in that case why? Appreciate your thoughts!