(1933) established that polynuclear aromatic hydrocarbons (PAHs) were carcinogenic components of pitch. ... Although less is known about their health effects than about those of PAHs, it is clear that some nitro-PAHs are potent mutagens and carcinogens.(1)
Benzene and polynuclear hydrocarbons containing more than two benzene rings fused together are toxic and said to possess cancer producing (carcinogenic) property. Such polynuclear hydrocarbons are formed on incomplete combustion of organic materials like tobacco, coal and petroleum.(2)
From the two sources cited above, I keep seeing that polybenzenoid compounds like 1,2-benzanthracene, 3-methylcholanthrene and 1,2- benzpyrene are mentioned to be carcinogens.
In general, why are polynuclear compounds carcinogenic? I google searched on this topic and all I could find is their effects and concentrations in various substances.
My questions are:
Why are they carcinogenic
Is there a reason for a given organic compound to be carcinogenic?