# R and T conformations in relation to Activators and Inhibitors; Km of reaction in relation to uncompetitive and non-competitive inhibitor

Do

-Activators

-Competitive Inhibitors

-Non-Competitive Inhibitors

-Uncompetitive Inhibitors

all change the conformation of the targeted enzyme from T to R (activator), and from R to T (the rest) respectively?

Also, why does the Km of a reaction decrease with an uncompetitive inhibitor, while remaining constant with a non-competitive inhibitor?

I have tried to find a coherent answer to this all across the internet, but to no avail. Many thanks!