# A question about thiamine [closed]

How does the the nitrogen of thiazole in thiamine acquire a positive charge without being stabilized by another negative charge or by being a salt of an anion?

• Even if it's not always reported, the thiamine you can buy or isolate is a salt: the thiamine molecule is a cation, and a counterion is present (typically Cl- or NO3-) – The_Vinz Dec 27 '19 at 17:34
• But this molecule doesn't enter my mind as being simply a cation, was the nitrogen atom neutral first then the hydrogen of methylene group attached to nitrogen was striped off by a strong alkali pushing the nitrogen to form a pi bond with the deprotonated group and acquiring a positive charge? – mohamed Dec 27 '19 at 18:37

Thiamine (Vitamin B1) has a positive charge on the nitrogen of thiazole ring, because that nitrogen is tetravalent. Thus, it should be neutralized by a counter ion. Usually, the counter ion is chloride ($$\ce{Cl-}$$) ion. Over-the-counter Vitamin B1 usually supplies as hydrochloride salt of thiamine chloride (simply called thiamine hydrochloride), which is very soluble in water.