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I'm having a hard time making a distinction between simple and complex enzymes. the definitions I've found so far all say this:

Simple enzymes are enzymes that are only made out of protein, and complex enzymes are ones that, in addition to the protein portion, have a non-protein portion as well, which is called a co-enzyme/prosthetic group (I've seen both terms being used)

Does this mean that any protein that utilizes a co-factor, even if that co-factor is simply a co-enzyme or an activating metal, i.e., not an actual part of the enzyme's structure, is considered a complex enzyme? Or are the two terms restricted to the structure of the enzyme (i.e., whether they have prosthetic groups, be they organic or inorganic, or not)?

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  • $\begingroup$ Having searched for the concept, it seems some people refer to an "enzyme-substrate complex" as a "complex enzyme". Your definition is something I haven't heard before. Maybe you can provide more context on where you first encountered the definition. $\endgroup$ – Buck Thorn Oct 1 at 18:42
  • $\begingroup$ The concept's explained in our college's lectures. I'm not sure what references the lectures are based on though. $\endgroup$ – Dahen Oct 1 at 19:42

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