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I work in a laboratory where gas chromatography is used extensively. We handle phthalates. What are the possible wash solvent for autosampler syringe? I've been using acetone.

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  • $\begingroup$ You could try use toluene a then ethyl acetate. $\endgroup$
    – GRSousaJr
    Sep 4 '19 at 12:46
  • $\begingroup$ Acetone is a remarkable solvent. Now if you use some phthalates which are either particularly polar or particularly non-polar, you may want to change the solvent. For really polar compounds, a mixture of methanol/water/acetonitrile may be great. For non-polar compounds, you may want to use dichloromethane. $\endgroup$
    – SteffX
    Nov 16 '19 at 13:29
  • $\begingroup$ I think Waters used to suggest a magic mix of 1:1:1:1 MeOH:IPA:ACN:water with a few drops of ammonia as a good way of clearing pthalates from lines - the same likely applies to autosampler needles $\endgroup$
    – NotEvans.
    Nov 4 at 21:22
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Methanol is less expensive. Don’t know how well it would work in your particular situation. We do semi volatiles (EPA 624) . Methanol works fine for the GC autosampler syringe.

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