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I read that serine isn't strongly acidic so how is it that in serine proteases it is able to have its pKa lowered by the catalytic triad?

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  • $\begingroup$ Could you edit to show a bit more what you already found out. For example, what is the pKa of serine in water, and what is it in the context of a serine protease? Also, how low do you think the pKa has to be in order for it to be a good catalyst? $\endgroup$ – Karsten Theis Jul 31 at 16:23

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