# Usage of TFA in Pfitzner-Moffat oxidation and Collins vs Jones oxidation

Is the addition of TFA in Pfitzner-Moffat oxidation to protonate the DCC to form a positive carbocation for the alcohol to attack? Or is there more to it? Why is TFA used and not other acids? Are other acids to weak for this?

Lastly for the Collins vs Jones oxidation, the only discernible differences are the solvent: $$\ce{H2SO4}$$ vs DCM, and that the Collins oxidation makes use of a pyridin chlorochromate, does this complex dampen the oxidative effect of chromium? So much so that the Collins oxidation can not directly oxidise a alcohol to a carboxylic acid, whereas Jones reagent with $$\ce{H2SO4}$$ and $$\ce{CrO3}$$ can?

• Actually, other acids have been employed (in the total synthesis of Camptothecin by Rapoport, phosphoric acid was used. The reaction took 30 hours) – The_Vinz Jul 17 '19 at 15:50
• chemistry.meta.stackexchange.com/questions/524/… – Mithoron Jul 17 '19 at 16:48
• The Collins oxidation employs the bis-pyridine complex of CrO3 in DCM. Pyridinium chlorochromate in DCM is the Corey-Suggs oxidation. – user55119 Jul 17 '19 at 19:58
• In the original communication of 1963 (JACS, 85, 3027), Moffatt and Pfitzner report that TFA serves poorly and HCl and H2SO4 do not work at all. All three work well as their pyridinium salts. H3PO4 was first one their list. – user55119 Jul 17 '19 at 20:27

About Collins vs Jones oxidation, both of them used chromium-based oxidants. Oxidations with chromium oxidants proceed through a similar mechanism. Different between Collins and Jones are conditions: Anhydrous (in pyridine/$$\ce{CH2Cl2}$$) vs aqueous (use of $$\ce{CH2Cl2}$$). Following is the suggested mechanism for chromium-based oxidants:
After first oxidation to aldehyde, chromium oxidant needs $$\ce{CH-OH}$$ part available to further oxidize to carboxylic acid (see in both mechanism, how oxidation initiated and finished). In anhydrous conditions, this feature is lacked. So, oxidation stops at aldehyde moiety. However, trace of water make aldehyde in equlibrium with its gem-diol moiety, which gives the necessary requirement of $$\ce{CH-OH}$$ feature. So, in Jones oxidation condition, oxidation will further continue to give carboxylic acids.